Spectroscopy of Biological and Materials Surfaces and Interactions


A concerted effort of the Han Group is the development of novel techniques and approaches, relying on electron and nuclear spin magnetic resonance that enables the study of biomolecular structure, dynamics and interaction with unprecedented sensitivity, resolution and information content. The Han Group relies on state of the art dynamic nuclear polarization (DNP)-enhanced nuclear magnetic resonance (NMR) spectroscopy and relaxometry, as well as electron paramagnetic resonance (EPR) tools. We are motivated by the power of “Seeing is Believing” to transform the study of biomolecular structure, molecular interactions, dynamics and functional processes with atomic and molecular-level insight.

Core questions of interest to the Han Group are directed towards:

  1. Magnetic Resonance Methods and Applications
  2. Tau Protein and Neurodegenerative Diseases
  3. Membrane Proteins Biophysics
  4. Characterization of Hydration and Interfaces

In short, an ambitious and general goal of the laboratory is to turn NMR from a bulk to a surface characterization tool, and in doing so access entirely novel information content and research utility in materials science and the biochemistry/biophysics of complex biomolecular systems. Find out more about our current work in the research section, or click on the publications tab to see what has been done so far.

We are overjoyed to announce that Alisa Leavesley has finished her PhD study on instrument development in dynamic nuclear polarization.

We are pleased to announce that Kendrick (Khanh) Nguyen, Miranda (Yuanxin) Li, Kate (Zhikai) Zeng, and Michael Vigers have all passed their candidacy exams.

A conference at UCSB will explore new possibilities in transformational science across disciplines.

UCSB’s terahertz free-electron laser is the only facility of its kind in the U.S.